The goal of the Al-Hashimi laboratory is to develop new methods for ‘imaging’ the dynamics of nucleic acids at atomic resolution.
The Axel Lab is primarily concerned with olfaction, or the sense of smell.
The Califano Lab studies biology from the perspective of the complex networks of gene and protein interactions that define and regulate cell physiology.
The Fitzpatrick Lab uses cryo-EM to solve the structures of filaments isolated from postmortem brain tissue of patients with a range of neurological disorders.
Frank Lab(link is external and opens in a new window)
The Frank Lab investigates the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction
Glasgow Lab(link is external and opens in a new window)
The Glasgow lab studies the molecular basis and evolution of protein allostery and designs new functional proteins for applications in therapeutics.
The Goff laboratory is interested in the replication of the Moloney murine leukemia virus, an oncogenic retrovirus, and Human Immunodeficiency Virus type 1, the cause of AIDS.
Greene Lab(link is external and opens in a new window)
The Greene Lab uses single-molecule optical microscopy to study fundamental interactions between proteins and nucleic acids.
Greenwald Lab(link is external and opens in a new window)
The Greenwald Lab studies cell-cell interactions, signal transduction, and cell fate specification during C. elegans development, with a focus on LIN-12/Notch.
The Hendrickson Lab focuses on the structure and function of biological molecules.
Hobert Lab(link is external and opens in a new window)
The Hobert Lab studies the gene regulatory control mechanisms that generate the astounding diversity of cell types in the nervous system.
The Honig Lab focuses on two distinct areas: the molecular basis of cell-cell recognition, and the use of structural information to predict protein function on a genome-wide scale.
The Kandel Lab studies explicit memory storage (the conscious recall of information about people, places, and objects) in mice and implicit memory storage in the snail Aplysia.
The Landweber Lab studies novel genetic systems in microbial eukaryotes, bringing a strongly mechanistic approach to understanding genome evolution and diversity.
The Lomvardas Lab aims to understand the molecular mechanisms of olfactory receptor gene choice.
The Maniatis lab is involved in understanding fundamental mechanisms of transcription and RNA splicing in the nervous system and how they bear on neuronal connectivity and neurodegenerative diseases.
The Mann Lab studies how the Hox family of transcription factors bind to the correct DNA sequences and regulate the correct target genes in vivo.
The Palmer Laboratory in the Department of Biochemistry and Molecular Biophysics uses NMR spectroscopy to study the structures and dynamical properties of proteins and other macromolecules.
The Shapiro Lab uses structural information obtained from X-ray crystallography to direct biochemical studies of biological problems.